Regulation of the human catalytic subunit of telomerase (hTERT)
نویسندگان
چکیده
منابع مشابه
Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase
BACKGROUND Telomeres consist of repetitive (TTAGGG) DNA sequences that are maintained by the multisubunit telomerase ribonucleoprotein. Telomerase consists of an RNA, which serves as template for the sequence tracts, and a catalytic subunit that functions in reverse transcription of the RNA template. Cloning and characterization of the human catalytic subunit of telomerase (hTERT) has supported...
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Telomerase, the enzyme that synthesizes telomeric DNA, is not expressed in most human somatic cells but is activated with in vitro immortalization and during tumorigenesis, and repressed by cell differentiation. Of the two components of the core enzyme, the catalytic protein hTERT is limiting for activity. To investigate mechanisms of hTERT gene regulation, we have cloned genomic sequences enco...
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15 صفحه اولThe catalytic subunit of yeast telomerase.
Telomerase is an RNA-directed DNA polymerase, composed of RNA and protein subunits, that replicates the telomere ends of linear eukaryotic chromosomes. Using a genetic strategy described here, we identify the product of the EST2 gene, Est2p, as a subunit of telomerase in the yeast Saccharomyces cerevisiae. Est2p is required for enzyme catalysis, as mutations in EST2 were found to result in the ...
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ژورنال
عنوان ژورنال: Gene
سال: 2012
ISSN: 0378-1119
DOI: 10.1016/j.gene.2012.01.095